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Researchers measured serum B12 and erythrocyte folate levels to determine deficiency rates, finding that 31% of adolescents were deficient in B12 and 35.6% in folate, with lower rates in preschool (13.8% for B12 and 22.8% for folate) and school-age children (17.3% for B12 and 27.6% for folate)

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NAD⁺ Pool Restoration: Increases availability of NAD⁺ for sirtuin and PARP activity, improving metabolic efficiency [Kannt 2015]